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Neural Signal Research

Where the brain's electrical language becomes a treatment protocol.

For patients whose conditions resist every name, we measure what other clinics cannot yet see — and build a path from that signal.

0+

Patients enrolled in active studies

0.0%

Diagnostic concordance rate

0

Novel biomarkers identified since 2019

Five research pathways below
01
Referral Intake

The corridor begins with one question: have other clinics stopped asking?

We accept patients through neurologist referral or direct self-referral. If your child has had three seizure medications fail, or your post-stroke plateau has lasted longer than the recovery window anyone quoted you — this intake is where that changes.

Our intake coordinators review every submission within three business days. You will receive either a screening call or a clear explanation of why this pathway may not be the right fit at this time. We do not maintain indefinite waitlists.

3 daysAvg. intake response
78%Of referrals proceed to imaging
Referral Screening Criteria
Two or more failed treatment courses
Documented EEG within 18 months
Neurologist referral or self-referral
Age 4 or older
Able to travel to center or participate remotely
Average intake response3 business days
02
Advanced Imaging

Four simultaneous imaging modalities. One integrated signal map.

Standard clinical EEG captures 30 minutes of activity on 21 electrodes. Our protocol runs 256-channel high-density EEG alongside fMRI, MEG, and metabolic PET — simultaneously, over multiple sessions — building a signal portrait that single-modality imaging cannot produce.

Sessions are designed around patient comfort. Sedation is available for pediatric patients. Remote telemetry options exist for monitoring phases following in-person baseline acquisition.

256-chEEG electrode density
4×Imaging modalities concurrent
Live signal preview
fMRI — Functional connectivity
EEG — High-density 256-channel
MEG — Millisecond timing
PET — Metabolic mapping
03
Biomarker Analysis

Six patterns no clinical lab currently tests for. Each one a map coordinate.

Since 2019, our analysis pipeline has identified six biomarkers absent from standard diagnostic panels — patterns in how neural signals couple, suppress, and propagate that correlate with specific treatment response profiles. These are not experimental guesses; each has published concordance data.

Biomarker analysis results are reviewed by a panel of three neurophysiologists before any protocol recommendation is generated. Families receive a written report in plain language alongside the technical summary.

97.3%Diagnostic concordance
6Novel biomarkers published
Identified Biomarkers6 novel
Avg. confidence90.2%
NMDA-R antibody pattern2019
94%
Theta-gamma coupling index2020
88%
Cortical spreading signature2021
91%
Astrocytic glutamate ratio2022
86%
Interictal discharge topology2023
93%
Post-ictally suppressed band2024
89%
04
Clinical Trial Matching

Your signal profile opens doors that general referrals cannot.

Biomarker findings are cross-referenced against our active trial registry and partner institution studies. Patients who match a trial profile receive a structured briefing — what the trial measures, what participation requires, what the exit criteria are — before any enrollment decision.

Participation in trials is always voluntary. Patients who do not match any active trial are not discharged from care; they enter our longitudinal monitoring cohort and are flagged automatically when new trials open.

4Active trials enrolling
63%Of patients match at least one trial
Active Trial Registry
Focal cortical dysplasia — SEEG mappingSYN-2024-01 · Phase II
Enrolling
7/12
Post-stroke aphasia — theta-burst TMSSYN-2024-03 · Phase II
Enrolling
14/20
FIRES — immunotherapy biomarker sub-studySYN-2023-07 · Observational
Active
28/30
Genetic epilepsy — SCN1A variant cohortSYN-2025-01 · Phase I
Opening Q2
0/15
05
Longitudinal Monitoring

The signal doesn't stop changing. Neither does the protocol.

Enrollment in longitudinal monitoring means your neural signal data is reviewed at 3, 6, 12, and 24-month intervals. Treatment protocols are adjusted based on signal drift — the small shifts in biomarker expression that precede both improvement and relapse.

Our 24-month outcome cohort shows a median 82% reduction in seizure frequency for enrolled patients. Post-stroke patients in the aphasia protocol show meaningful language recovery at 18 months in 71% of cases — compared to 34% in matched clinical controls.

82%Median seizure reduction at 18mo
71%Language recovery (aphasia cohort)
24-Month Outcome CohortMedian 82% reductionin seizure frequency by month 18
Quality-of-life index (patient-reported)
Monthly seizure frequency
M1
M3
M6
M9
M12
M18
M24
Begin the process

Clarity is possible. We can help you find it.

If your condition has resisted three opinions, two medication trials, or a year without answers — the work here is designed for exactly that uncertainty.

No obligation. Screening takes approximately 8 minutes.